Senior Scientist (R3), AI/ML for Protein Design

Merck

South San Francisco, CA 94080

Posted 5 days ago

Job Description

**Job Description**


New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in customer facing commercial or research based roles, will be required to be fully vaccinated as a condition of employment.


Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.


Our company's Research Laboratories South San Francisco, a wholly owned subsidiary of our company, is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of-the-art resources to explore the most promising science combined with our company world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay Area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of our company's powerful world-class network of drug and vaccine discovery.


At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.


Our company is currently seeking a highly motivated and exceptional scientist with a focus on advanced AI/ML approaches for biologics, protein, and peptide modeling in the Modeling & Informatics group within the Computational and Structural Chemistry department at our South San Francisco site. The successful candidate will join multidisciplinary, highly collaborative discovery teams both locally and across our company's global network to invent novel medicines by applying advanced computational techniques and developing innovative computational methods.


**Key Responsibilities:**


+ Developing new workflows, including deep learning workflows, that enable the discovery of new medicines


+ Contributing to protein design for therapeutics, antigens, and structure enablement


+ Collaborate with interdisciplinary discovery teams to apply a variety of informatics and modeling techniques to accelerate the evolution of drug discovery leads to drug candidates


+ Continuing research in areas of machine learning and molecular modeling relevant to drug discovery, and maintaining an external scientific presence through high-impact publications and presentations


+ Education and sharing of AI/ML knowledge across the department and adjacent groups


**Position Qualifications:**


Required Education:


+ MS/MA with a minimum of 4 years post-graduate experience or Ph.D. (or close to completion) in biophysics, biochemistry, chemistry, computer science, applied math, engineering, or equivalent


Required Experience:


+ Experience applying advanced computational approaches to protein and/or peptide design


+ Proficiency in Python for scientific computing


+ Experience with at least one major deep learning framework (PyTorch, TensorFlow, JAX, or similar)


+ Knowledgeable in machine learning best practices


+ Experience with Linux and high-performance compute (HPC) environments


+ Multiple publications and/or external presentations demonstrating creative application of computational approaches to problems of biological interest


+ Strong written and oral communication skills


Preferred Experience:


+ Ability to develop computational workflows, analysis methodologies, or algorithms for biomolecules such as peptides, proteins, antibodies, and antibody drug conjugates.


+ Experience with protein design software packages such as MOE, Schrodinger, or Rosetta


+ Experience applying computational methods such as molecular dynamics, protein sequence/structure design, or deep learning to problems of biological interest


+ Experience working in multidisciplinary teams that include experimental scientists


We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.


**Who we are …**


We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.


**What we look for …**


Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


**NOTICE FOR INTERNAL APPLICANTS**


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.


If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.


**Residents of Colorado**


Click here (https://survey.sogosurvey.com/Survey1.aspx?k=SsQYWYYQsQRsPsPsP&lang=0) to request this role’s pay range.


\#EligibleforERP


\#CSCjobs


**New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.**


Current Employees apply HERE (https://wd5.myworkday.com/msd/d/inst/1422$1533/rel-task/3001$14.htmld)


Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)


**US and Puerto Rico Residents Only:**


Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.


For more information about personal rights under Equal Employment Opportunity, visit:


EEOC Poster (https://www.dol.gov/sites/dolgov/files/ofccp/regs/compliance/posters/pdf/eeopost.pdf)


EEOC GINA Supplement?


OFCCP EEO Supplement (https://www.dol.gov/ofccp/regs/compliance/posters/pdf/OFCCP\_EEO\_Supplement\_Final\_JRF\_QA\_508c.pdf)


Pay Transparency Nondiscrimination


We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.


**Residents of Colorado:**


Click here (https://survey.sogosurvey.com/Survey1.aspx?k=SsQYWYYQsQRsPsPsP&lang=0) to request this role’s pay range.


**Search Firm Representatives Please Read Carefully**


Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.


**Employee Status:**


Regular


**Relocation:**


Domestic/International


**VISA Sponsorship:**


Yes


**Travel Requirements:**


**Flexible Work Arrangements:**


**Shift:**


**Valid Driving License:**


**Hazardous Material(s):**


**Number of Openings:**


2


**Requisition ID:** R167026



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